Bioactive Secondary Metabolites from Marine <em>Streptomyces griseorubens</em> f8: Isolation, Identification and Biological Activity Assay
2021
Wenzhi Yang | Guangjie Liang | Yang Sun | Zhijin Gong
Marine actinomycetes are a potential source of a wide variety of bioactive natural products. Herein, four cyclic dipeptides, namely, cyclo(L-Val-L-Pro) (compound 1), cyclo(L-Pro-L-Leu) (compound 2), cyclo(L-Pro-L-Tyr) (compound 3) and cyclo(L-Pro-L-Phe) (compound 5), and an <i>N</i>-acetyltyramine (compound 4) were first isolated and identified as products of the marine <i>Streptomyces griseorubens</i> f8. Compounds 3 and 5 exhibit antibacterial activity against <i>Staphylococcus aureus</i>, <i>Klebsiella aerogenes</i> and <i>Proteus vulgaris</i>. The minimum inhibitory concentrations (MICs) against <i>Staphylococcus aureus</i>, <i>Klebsiella aerogenes</i> and <i>Proteus vulgaris</i> are 160 µg/mL, 100 µg/mL, 120 µg/mL for the compound 3 and 180 µg/mL, 130 µg/mL 150 µg/mL for the compound 5, respectively. In addition, compounds 1, 2, 3 and 5 was first found to have the ability to inhibit the invasion and migration of A549 cells (lung cancer cells), which exhibited the potentiality for these compounds to be used as novel anticancer drugs. This study provides a novel production strain for compounds 1, 2, 3 and 5, and four potential promising anticancer agents.
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