Classicalandmodernconceptsof inbreedingand effects of inbreedingdepression in animals
2016
S. Tanchev
Abstract. An overview of the literature on inbreeding and inbreeding depression in animals was made with focus on the development of scientific concepts from Darwin times to present days. The opinions and hypothesis of numerous researchers about the genetic nature of these events are presented. The effects of inbreeding on different biological traits of animals and manifestations of inbreeding depression as a possible result of various allele and gene interactions are discussed.Theanalysisofinformationdemonstratedthatdespitethenewbodyofknowledgeaboutinbreeding and inbreeding depression accumulatedduring thelast 10–15 years, someissuesarestillnotclearthusposingimportant research tasks to genetics. They are associated to: 1. Thenumberofgenes, the natureandfeaturesofspecificalleleandgeneinteractionswhichdetermineinbreedingdepression; 2. Theinvestigationanddiscoveryofgenesmutations relatedtothisevent; 3. Performanceofstructuralandfunctionalanalysesofgenes, RNAtranscripts, proteinsandmetabolitesrelatedtoinbreeding depression; 4. Investigation of the interaction of inbred genotypes with environmental factors etc. Fromafutureperspective, theauthorbelievesthatintheomic technologiesera, thelong-standingtopicaboutinbreeding andinbreedingdepressioncouldacquiresanew meaning andrenewtheinterestofscientists. In conclusion, theimplementationofmoderntechnologiesofresearchcouldassistforgatheringnewdetailedinformationaboutthegeneticnatureofinbreeding and theeffectsofinbreedingdepression.
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