DIAGNOSTICS OF METABOLIC VIOLATIONS IN ORGANISM OF COWS IN A PERIOD FOR THE PURPOSE AND DEVELOPMENT OF PREVENTIVE MEASURES

The article presents an analysis of the results of biochemical studies of blood serums from selected cows in the Rivne region during the period of the cattle for the purpose of early diagnosis of metabolic disorders. It has been established that in serum of blood of cows, the parameters of protein, hydrocarbon and fat metabolism and the level of certain mineral substances and vitamins, namely total protein, albumin, glucose, total cholesterol and vitamins A and E, total calcium and inorganic phosphorus, are lowered relative to the lower level of their reference values. It is also found that there is a shortage of Zinc, Kuprum, Manganese, Selenium and Cobalt in the body. On the basis of the obtained data, measures for the normalization of metabolic processes of domesticated cows have been developed, which include providing the body with an energy substrate, increasing the level of glucose in the blood, minimizing the load on the liver and pancreas, and reducing the toxic effects of various intermediate digestive products. The plan of preventive measures including the use of vitamin-mineral preparation "Energolit" (vitamins B1, B2, B3, B5, B6, B12, glucose, sorbitol, sodium acetate, sodium, potassium, calcium and magnesium chlorides, arginine, glutamic acid, lysine, methionine). The solution was injected immediately after calving intravenously, once a day, for 3 days in a dose of 50-100 ml per 100 kg body weight. Lack of vitamins A and E and Cobalt was normalized by introducing into the diet of newborn cows "Vitamin Bland for VLC 0.2%", powder form (vitamins: A, D3, E and minerals Cobalt and Iodine), 1,0 g per 10 kg of body weight, once a day for 14 days. After injection of Energolit, correction of mineral nutrition of cattle was maintained at the expense of the oral administration of Calfimin containing Calcium, Phosphorus, Magnesium, Natrium, Manganese, Zinc, Kuprom, Cobalt, Methion and Lysine, at a rate of 1,0 ml per 10 kg of body weight 1 time per day for 14–20 days. Lack of Selenium was normalized by the introduction of sodium selenite, in the form of subcutaneous injections of the drug Devivit Selen - 1 ml of the drug for 50 kg of body weight, 2 times at intervals of 7 days. Already in the 3rd day after application of "Energolit" glucose content increased by 7,6% (1,98±0,06 mmol/l), for the 6th day – by 29,9% (2,39±0, 07 mmol / l), at the 14th day it was 3,01±0,06 mmol / l with a primary index of 1,84 ± 0,06 mmol/L. By analogy, it was also observed with other indicators that were underestimated relative reference levels. In the studies after the applied preventive treatment plan, none of the experimental animals showed signs of postpartum paresis and ketosis.