Immunological properties of the bacterial origin compounds
2016
А. Kapustyan | N. Cherno
It is shown that microorganisms are an integral element of the mаcroorganism immune system.<br />Peptidoglycan, muramyldypeptyd, teichoic acids are structural components of cell walls of microorganisms. These components<br />are an object for recognition of the innate immunity system. The necessity of the bacteria cell walls destruction with a view to<br />obtain the immunotropic products for enteral consumption, able to overcome the intestinal barrier, was substantiated.<br />The use of lactic acid bacteria (ICD) for such purposes is perspective and safe, since the considerable experience of<br />their cultivation was accumulated, in addition, ICD have got «GRAS» (Generally Recognized As Safe) status. Waste products<br />of ICD are organic acids, hydrogen peroxide, bacteriocins and others. These substances have got antagonist activity, implicitly<br />affect on the immune system, reducing the antigenic load caused by pathogenic microorganisms.<br />A number of physical, chemical and biochemical methods of bacteria cell walls destruction were considered. The<br />priority methods is the soft influence, namely the use of specific enzymes or hydrolases, own autolyzins with a combination of<br />physical destruction methods.
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