Molecular antioxidant and immunological mechanisms of phytogenics in the mitigation of aflatoxicosis in poultry

SUMMARY: The poor quality and safety of poultry feed in developing countries pose significant concerns as they negatively impact poultry performance and present potential health risks to human consumers. Aflatoxicosis, resulting from postharvest contamination of feed ingredients by certain mold species, severely affects birds' overall health and productivity. To address these challenges, various feed additives have become increasingly important in poultry nutrition. Phytogenics, natural plant-derived products, have gained popularity for their ability to mitigate aflatoxicosis by their rich composition of bioactive compounds that offer beneficial effects on physiological and immunological functions. In light of the growing significance of aflatoxicosis in poultry nutrition, this review provides an overview of aflatoxins and their harmful effects on poultry health. It highlights the role of phytogenic compounds as growth and health stimulators, emphasizing their potential application in poultry nutrition. Furthermore, the review explores the antioxidant and immunological mechanisms through which phytogenics mitigate aflatoxicosis in poultry, including specific compounds and pathways involved. The findings reveal that aflatoxins induce inflammation, and oxidative stress in poultry, resulting in cellular damage and immune dysfunction. Phytogenics play a crucial role in ameliorating the harmful effects of aflatoxins in birds by countering aflatoxin-induced oxidative stress, reducing inflammation, and restoring gut health and immune functions. In conclusion, phytogenics offer an invaluable tool for the mitigation of aflatoxicosis in poultry and serve as potent natural and safe alternatives to antibiotics and synthetic antioxidants, promoting sustainable production practices.