Metformin represses drug – induced expression of CYP2B6 by the constitutive androstane receptor phosphorylation

Metformin represses drug – induced expression of CYP2B6 by the constitutive androstane receptor phosphorylation

2014

Currently, metformin is a major hypoglycemic agents for the treatment of type 2 diabetes. The main antihyperglycemic effect of metformin - suppression of hepatic gluconeogenesis and glycolysis. However, type 2 diabetes are usually associated with other diseases and associated comorbid conditions that require polifarmakologic treatment.

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