A serine protease secreted from Bacillus subtilis cleaves human plasma transthyretin to generate an amyloidogenic fragment

Daniele Peterle; Giulia Pontarollo; Stefano Spada; Paola Brun; Luana Palazzi; Alexej V. Sokolov; Barbara Spolaore; Patrizia Polverino de Laureto; Vadim B. Vasilyev; Ignazio Castagliuolo; Vincenzo De Filippis

A serine protease secreted from Bacillus subtilis cleaves human plasma transthyretin to generate an amyloidogenic fragment

2020

Peterle et al. show that a subtilisin like serine protease secreted from gut microbiota Bacillus subtilis cleaves the wild-type human transthyretin (hTTR) to generate an amyloidogenic peptide. High propensity of the hTTR fragment to form pathogenic protein aggregates implicates the serine protease in the pathogenesis of acquired senile systemic amyloidosis.

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