GFI1 tethers the NuRD complex to open and transcriptionally active chromatin in myeloid progenitors

Anne Helness; Jennifer Fraszczak; Charles Joly-Beauparlant; Halil Bagci; Christian Trahan; Kaifee Arman; Peiman Shooshtarizadeh; Riyan Chen; Marina Ayoub; Jean-François Côté; Marlene Oeffinger; Arnaud Droit; Tarik Möröy

GFI1 tethers the NuRD complex to open and transcriptionally active chromatin in myeloid progenitors

2021

Helness et al. show that GFI1/CHD4 complexes critically regulate chromatin accessibility and histone modifications to regulate target genes affecting diverse cellular processes in neutrophils. Their results provide further insight into the molecular network operated by GFI1 for neutrophil differentiation programs.

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