A common evolutionary origin reveals fundamental principles of protein insertases.

F-Nora Vögtle; Hans-Georg Koch; Chris Meisinger

A common evolutionary origin reveals fundamental principles of protein insertases.

2022

F-Nora Vögtle | Hans-Georg Koch | Chris Meisinger

Membrane proteins require protein machineries to insert their hydrophobic transmembrane domains (TMDs) into the lipid bilayer. A functional analysis of protein insertases in this issue of PLOS Biology reveals that the fundamental mechanism of membrane protein insertion is universally conserved.

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