Characterization of the Zebrafish Cell Landscape at Single-Cell Resolution
2021
Mengmeng Jiang | Mengmeng Jiang | Mengmeng Jiang | Yanyu Xiao | Weigao E | Lifeng Ma | Jingjing Wang | Jingjing Wang | Jingjing Wang | Haide Chen | Haide Chen | Haide Chen | Ce Gao | Yuan Liao | Qile Guo | Jinrong Peng | Xiaoping Han | Xiaoping Han | Guoji Guo | Guoji Guo | Guoji Guo
Zebrafish have been found to be a premier model organism in biological and regeneration research. However, the comprehensive cell compositions and molecular dynamics during tissue regeneration in zebrafish remain poorly understood. Here, we utilized Microwell-seq to analyze more than 250,000 single cells covering major zebrafish cell types and constructed a systematic zebrafish cell landscape. We revealed single-cell compositions for 18 zebrafish tissue types covering both embryo and adult stages. Single-cell mapping of caudal fin regeneration revealed a unique characteristic of blastema population and key genetic regulation involved in zebrafish tissue repair. Overall, our single-cell datasets demonstrate the utility of zebrafish cell landscape resources in various fields of biological research.
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