Compensatory mechanisms in resistant Anopheles gambiae AcerKis and KdrKis neurons modulate insecticide-based mosquito control

Stéphane Perrier; Eléonore Moreau; Caroline Deshayes; Marine El-Adouzi; Delphine Goven; Fabrice Chandre; Bruno Lapied

Compensatory mechanisms in resistant Anopheles gambiae AcerKis and KdrKis neurons modulate insecticide-based mosquito control

2021

Perrier et al. examine the neurons of mosquitoes following the development of insecticide resistance-associated point mutations in the voltage-gated sodium channels and AChE1 genes for two resistant strains, KdrKis and AcerKis. Their results show that nAChRs and the intracellular calcium concentration provide a compensatory mechanism for AcerKis and KdrKis neurons to insecticide exposure.

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