Short chain fatty acids pattern in rat intestine content under nipasol effect
2014
Ya. I. Kolisnyk | V. V. Lytvyn | N. B. Skochylyas
The qualitative and quantitative composition of the short chain fatty acids (SFA) (acetic, propionic, butyric, isovaleric, valeric and capric) in the colonic content of the rats, which were orally given preservative nipasol (10 mg/kg) has been studied. It was shown that the content of acetic acid was lower on the 7-th and 14-th days of the experiment in comparison with control group of animals. The amount of propionic and butyric acids in the colonic content was increased on the 7-th day, but on the 14-th days of the experiment it was decreased, however, this amount was higher, than in control group of rats. Concentrations of isovaleric and valeric acids on the 7-th and 14-th days of the experiment exceeded normal limits. After cessation of nipasol introduction on the 7-th day (21-th day of the experiment) the amount of fatty acids almost returned to baseline. Analysis of C2-C4-acids profile after nipasol introduction revealed a decrease in the concentration of acetic acid and an increase in the levels of butyric and propionic acids. Obtained results provide a possibility to suggest that the level of SFA in the colonic content is an important indicator of changes in gastrointestinal microbocenosis under the influence of different factors.
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