Somatostatin receptor 1,2 and 5 activation leads to C6 glioma growth arrest in vitro and in vivo; analysis of the intracellular pathways involved
2011
M. Gatti | A. Pattarozzi | R. Würth | F. Angeletti | F. Barbieri | T. Florio
We report that somatostain receptor (SSTR) 1,2 and 5 activation by selective agonista, cause C6 cell growth arrest through PTPn-dependent dephosphorylation of ERK1/2 in vitro and after xenografting in nude mice. Individual SSTR agonist desplayed different efficacy and potecy showing partial synergism by combined treatment. Since most tumor cells express multiple SSTRs, the activtion of all the subtypes may grant a better control of cancer growth.
显示更多 [+] 显示较少 [-]AGROVOC关键词
书目信息
出版者
PAGEPress Publications
其它主题
Somatostatine receptor; Gliomas
语言
英语
2024-12-11
2025-10-24
DOAJ