Immunobiological reactivity of the body in cows with ovarian dysfunction

It is known that the immune status of the female organism changes dynamically at all stages of both the physiological and pathological state of the reproductive system. The work presents the results of scientific research and analysis of immunological studies in cows with ovarian dysfunction. We studied the nature and peculiarities of the relationships between the indicators of immunity and sexual function of infertile cows before and after treatment. The purpose of the research was to find out the dynamics of some morphological and biochemical blood indicators and the immune status of the body in cows with functional disorders of the ovaries. Certain regularities of the immune status in cows with persistent corpus luteum of the ovary and hypofunction of the ovaries have been established. The results of our research confirmed and supplemented previously established data on changes in hematological and immunological indicators in cows with ovarian pathology. It was established that the development of this pathology was accompanied by an immunodeficient state of the body, disorders of the cellular and humoral links of immunity, and a decrease in indicators of non-specific protection. Ovarian dysfunction in cows mainly develops against the background of immunosuppression and deficiency of indicators of cellular protection of the body, which was supplemented by a decrease in the content of erythrocytes, hemoglobin and total protein in the blood. A significant increase in the content of “0” mononuclear cells in the blood of sick cows indicates a violation of the mechanisms of lymphocyte differentiation, which negatively affects the formation of the body’s immune response. The imbalance of individual lymphocyte populations indicates the need for immunocorrection in order to increase the content of B and T cells, which will, accordingly, lead to a decrease in the share of low-active “0”-lymphocytes, and will contribute to the restoration of the immune defense mechanisms of the cows’ body. The decrease in indicators of individual factors of immunobiological reactivity of the body of cows with gonadal pathology substantiates the need for the use of general stimulating drugs with an immunomodulating effect.