Oxidative Stress and Inflammation in SARS-CoV-2- and <i>Chlamydia pneumoniae</i>-Associated Cardiovascular Diseases
2021
Simone Filardo | Marisa Di Pietro | Fabiana Diaco | Silvio Romano | Rosa Sessa
Throughout the years, a growing number of studies have provided evidence that oxidative stress and inflammation may be involved in the pathogenesis of infectious agent-related cardiovascular diseases. Amongst the numerous respiratory pathogens, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus responsible for the global ongoing pandemic, and <i>Chlamydia pneumoniae</i>, a widely known intracellular obligate bacteria, seem to have an essential role in promoting reactive oxygen species and cytokine production. The present review highlights the common oxidative and inflammatory molecular pathways underlying the cardiovascular diseases associated with SARS-CoV-2 or <i>C. pneumoniae</i> infections. The main therapeutic and preventive approaches using natural antioxidant compounds will be also discussed.
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