MORPHOMETRY OF THE CORONARY OSTIA IN WOMEN: AN ANGIOGRAPHIC STUDY

Introduction. Cardiovascular diseases remain the main cause of death worldwide. Coronary heart disease is most common among women causing early mortality, disability, and reduced quality of life. Purpose. To conduct a morphometric analysis of the coronary ostia in healthy women and in female patients with coronary artery disease assessing the interrelationship of age-anthropometric indicators. Materials and methods. Angiographic images of coronary arteries of healthy women (24 people) and women with coronary heart disease (32 people). Methods used were coronary angiography, mathematical and statistical calculations. Results. The height of the left coronary artery ostium (4.78±1.16 mm) is significantly bigger than the height of the right coronary artery ostium (3.94±0.98 mm) in women with coronary artery disease (p=0.003). Under normal conditions, similar differences were established: the height of the left coronary artery ostium 5.96±0.91 mm, and the height of the right coronary artery ostium 4.58±1.10 mm (p<0.0001). The height of the ostia of the left (p=0.0001) and right (p=0.027) coronary arteries was bigger in healthy people compared to the group with coronary heart disease. The analysis of the combined effect of several factors on the size of the vessels showed that as the age of the patients increased, height (r=-0.35, p=0.047) and body surface area (r=-0.37, p=0.035) decreased. Height was directly correlated with body weight (r=+0.36, p=0.043). The results of a pairwise correlation study in a group of healthy women confirmed the presence of a direct relationship of medium strength between the parameters of both coronary arteries (r=+0.42, p=0.043), but showed the absence of a proven relationship between the values of the height of the coronary ostia and ageanthropometric indicators (p>0.05). When studying the complex influence of factors on the parameters of the studied vessels, a combined relationship between age and body surface area which had impact on the height of the right coronary ostium, as well as age and body weight influence on the height of the left coronary ostium were established. However, the pairwise correlation analysis did not establish a significant relationship between age and anthropological parameters. In healthy women, as well as in those with coronary artery disease, a direct correlation of medium strength with body weight (r=+0.49, p=0.014) and with the body surface area indicator (r=+0.63, p =0.001) was proved. Conclusions. Various interrelationships between the height of the right and left coronary ostia and age, height, weight, body mass index, and body surface area in women with andwithout coronary artery disease were established.