Rearrangement processes and structural variations show evidence of selection in oesophageal adenocarcinomas

Alvin Wei Tian Ng; Gianmarco Contino; Sarah Killcoyne; Ginny Devonshire; Ray Hsu; Sujath Abbas; Jing Su; Aisling M. Redmond; Jamie M. J. Weaver; Matthew D. Eldridge; Simon Tavaré; Oesophageal Cancer Clinical and Molecular Stratification  Consortium; Paul A. W. Edwards; Rebecca C. Fitzgerald

Rearrangement processes and structural variations show evidence of selection in oesophageal adenocarcinomas

2022

Genomic structural variants (SVs) in cancer are notoriously difficult to identify, despite the impact they have on cancer progression and treatment efficacy. This study applies state-of-the-art computational methods to catalogue SVs in 383 cases of oesophageal cancer, uncovering mutational patterns and new disease drivers.

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