Zorrimidazolone, a Bioactive Alkaloid from the Non-Indigenous Mediterranean Stolidobranch Polyandrocarpa zorritensis
2011
Rocco Vitalone | Rita Santamaria | Concetta Imperatore | Carlo Irace | Marialuisa Menna | Paolo Luciano | Ernesto Fattorusso | Anna Aiello
Chemical analysis of the Mediterranean ascidian Polyandrocarpa zorritensis (Van Name 1931) resulted in the isolation of a series of molecules including two monoindole alkaloids, 3-indolylglyoxylic acid (3) and its methyl ester (4), 4-hydroxy-3-methoxyphenylglyoxylic acid methyl ester (1) and a new alkaloid we named zorrimidazolone (2). The structure of the novel compound 2 has been elucidated by spectroscopic analysis and bioactivity of all compounds has been investigated. Zorrimidazolone (2) showed a modest cytotoxic activity against C6 rat glioma cell line.
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