The Rabs: A family at the root of metazoan evolution
2012
Stenmark Harald
<p>Abstract</p> <p>Eukaryotic cells are distinguished by their compartmentalization into membrane-enclosed organelles that exchange membranes and content in a highly ordered manner. Central in defining membrane identity are the Rabs, a large family of small GTPases that localize to distinct membranes and recruit specific regulators of membrane traffic. Two recent papers, including one by Klöpper <it>et al</it>. in <it>BMC Biology</it>, present phylogenomic evidence that the Rab repertoire was established very early in eukaryotic evolution, and correlates with interspecies variations in organelles.</p> <p>See research article <url>http://www.biomedcentral.com/1741-7007/10/71</url></p>
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