Derivation of iPSC lines from two patients with familial Alzheimer's disease from India
2019
Ashaq H. Najar | K.M. Sneha | Aparna Ashok | Swathy Babu | Anand G. Subramaniam | Ramkrishnan Kannan | Biju Viswanath | Meera Purushottam | Mathew Varghese | Suhel Parvez | Mitradas M. Panicker | Odity Mukherjee | Sanjeev Jain
The current prevalence of diagnosable dementia in India is 1% of people over 60 years (~3.7 million people), but is estimated to increase significantly, as ~15% world's aged population (>65 years) would be resident here by 2020 (Shah et al., 2016). While several mutations that pose a familial risk have been identified, the ethnic background may influence disease susceptibility, clinical presentation and treatment response. In this study, we report a detailed characterization of two representative HiPSC lines from a well-characterized dementia cohort from India. Availability of these lines, and associated molecular and clinical information, would be useful in the detailed exploration of the genomic contribution(s) to AD.
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