cPEPmatch Webserver: A comprehensive tool and database to aid rational design of cyclic peptides for drug discovery
2024
Brianda L. Santini | Stephanie Wendel | Niklas Halbwedl | Asha Knipp | Martin Zacharias
Cyclic peptides have emerged as versatile scaffolds in drug discovery due to their stability and specificity. Here, we present the cPEPmatch webserver (accessible at https://t38webservices.nat.tum.de/cpepmatch/), an easy-to-use interface for the rational design of cyclic peptides targeting protein-protein interactions combined with a semi-quantitative evaluation of binding stability. This platform also offers access to a comprehensive database of cyclic peptide crystal structures. We demonstrate the webserver's utility through a series of case studies involving medically relevant protein systems, highlighting its potential to significantly advance drug discovery efforts.
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