In silico DETERMINATION OF T-EPITOPES OF Mycobacterium tuberculosis PROTEINS
2013
O. I. Krynina | D. V. Kolibo | S. V. Komisarenko
The comparative analysis of 8 antigens of Mycobacterium tuberculosis (MPT83, MPT63, ESAT-6, CFP10, SodA, leuD, panD and HBHA) in silico to determine T-epitopes that can bind MHC class II molecules coding the most common in Eastern Europe HLA-DRB1 alleles was the goal of the work. The results show that the most immunogenic proteins are SodA, MPT83, leuD and MPT63, which has the largest number of T-epitopes for the alleles of interest. Accordingly, these antigens or their combinations could be promising candidates for development of new vaccines and diagnostics to form anti-TB immunity in Eastern European region and to determine the state of protection of the population.
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