Exploration of the main sites for the transformation of normal prion protein (PrPC) into pathogenic prion protein (PrPsc)

Liu Xi-Lin; Feng Xiao-Li; Wang Guang-Ming; Gong Bin-Bin; Ahmad Waqas; Liu Nan-Nan; Zhang Yuan-Yuan; Yang Li; Ren Hong-Lin; Cui Shu-Sen

Exploration of the main sites for the transformation of normal prion protein (PrPC) into pathogenic prion protein (PrPsc)

2017

Introduction: The functions and mechanisms of prion proteins (PrPC) are currently unknown, but most experts believe that deformed or pathogenic prion proteins (PrPSc) originate from PrPC, and that there may be plural main sites for the conversion of normal PrPC into PrPSc. In order to better understand the mechanism of PrPC transformation to PrPSc, the most important step is to determine the replacement or substitution site.

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