Genotoxicity and mutagenicity of inosine pranobex

Tobólska Sylwia; Terpiłowska Sylwia; Jaroszewski Jerzy; Siwicki Andrzej Krzysztof

Genotoxicity and mutagenicity of inosine pranobex

2018

Tobólska Sylwia | Terpiłowska Sylwia | Jaroszewski Jerzy | Siwicki Andrzej Krzysztof

Inosine pranobex (Methisoprinol, ISO, Isoprinosine) is an immuno-modulatory antiviral drug that has been licensed since 1971 in several countries worldwide. In humans, the drug is approved for the treatment of viral infections, and it might also have therapeutic use in animals. The aims of the presented work were to investigate the genotoxicity of inosine pranobex on BALB/3T3 clone A1 and HepG2 cell lines and to elucidate its mutagenicity using the Ames test.

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