Influence of a subinhibitory concentration of vancomycin on the in vitro expression of virulence-related genes in the vancomycin-resistant enterococcus faecalis
2015
Moura, Tiane Martin de | Campos, Fabrício Souza | Caierão, Juliana | Roehe, Paulo Michel | D'Azevedo, Pedro Alves | Frazzon, Jeverson | Frazzon, Ana Paula Guedes
Introduction: Exposure to subinhibitory concentrations (SICs) of antimicrobials may alter the bacterial transcriptome. Methods: Here, we evaluated the expression of nine virulence-related genes in vancomycin-resistant enterococci (VRE) urinary tract infection isolates grown at SICs of vancomycin. Results: A Subinhibitory concentrations of vancomycin interferes with gene modulation, but does not affect the phenotype of a VRE strain in vitro. Conclusions: Subinhibitory concentrations of vancomycin may regulate the expression of virulence factors in vivo or contribute to the selection of vancomycin-resistant strains.
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