Changes in the prevalence of antibodies over time following canine core vaccination
2016
Soma, T. (Marupi Lifetech Co. Ltd., Ikeda (Japan). Veterinary Diagnostic Laboratory) | Kawaguchi, M. | Takagi, H. | Saito, N.
Changes in the immune status in response to canine distemper virus (CDV), canine parvovirus type 2 (CPV-2), canine adenovirus type 1 (CAdV-1), and canine adenovirus type 2 (CAdV-2) over the course of several years after vaccination were examined using sera obtained from 178 dogs older than 24 months. Our results showed that the decline in the effects of the vaccine and antibody levels were associated with the number of years that had elapsed since vaccination in all four virus groups. In addition, the coefficient of variation for the antibody level was markedly elevated in the CDV, CAdV-1, and CAdV-2 groups two years after vaccination. Based on these findings, we concluded that the reduced antibody level shows a more rapid rate of decline with the passage of time after vaccination, and thus it is conceivable that individual differences in the immune status will be greater. Therefore, it is considered necessary to regularly monitor the immune status by conducting antibody tests on dogs for which vaccination should be avoided for reasons such as immune-related diseases.
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