Effects of D-allulose on glucose metabolism after the administration of sugar or food in healthy dogs
2016
Nishii, N. (Gifu University, Gifu (Japan). Faculty of Applied Biological Sciences, Joint Department of Veterinary Medicine) | Nomizo, T. | Takashima, S. | Matsubara, T. | Tokuda, M. | Kitagawa, H.
D-allulose is a C-3 epimer of D-fructose and has recently been investigated for its hypoglycemic effects. In the present study, the effects of D-allulose on glucose metabolism were evaluated in healthy dogs administrated sugar or food. The oral administrations of D-allulose decreased plasma glucose concentrations after oral glucose or maltose administration, with a diminished plasma insulin rise. The glucose suppressive effect of D-allulose was also observed after intravenous glucose administrations without increase in plasma insulin concentration. In contrast, D-allulose showed no effect on plasma glucose and insulin concentrations after feeding. The present results suggest that D-allulose administration may be beneficial in dogs with impaired glucose tolerance. Further studies investigating the therapeutic efficacy of D-allulose in diabetic dogs are required.
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