Case of true hermaphroditism with XY karyotype in a Holstein heifer
2020
Suzuki, K. (Nihon University College of Bioresource Sciences, Fujisawa (Japan)) | Sumiyoshi, T. | Watanabe, T. | Kondo, H. | Shibuya, H. | Iwasa, M.A. | Ohtaki, T. | Horikita, T.
An examination aimed at sex determination was carried out at Nihon University Animal Medical Center for a Holstein heifer with suspected hermaphroditism. Cytogenetic analysis of blood cells confirmed the presence of the Y chromosome (2n = 60, XY) in 95 cells, and molecular analysis revealed the presence of the Sex-determining region Y (Sry) gene in blood cells. Plasma testosterone (T) level was found to be low in a human chorionic gonadotropin (hCG) blood test. The anti-Müllerian hormone (AMH) level was 0.02 ng/ml. In a pathological examination, the existence was confirmed for ovaries, a uterus, a cervix and a vagina. The animal exhibited external genitalia that continued from the vagina, located 36 cm below the anus. The left ovary-like structure was interspersed with small follicle-like structures and seminiferous tubule-like structures. On the right side, in addition to the same findings as the left side, multiple large cystic structures were observed. Based on these results, the cow was diagnosed with true hermaphroditism (XY/female). When the T and AMH levels are low and do not respond to the hCG blood test, as in this case, it can be judged that there is no functional testis, and it is considered that there is no adverse effect (such as the deterioration of meat quality, management becomes difficult due to the expression of male character) even if fattening is implemented without treatment.
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