Microbiota modulatory properties of novel non-digestible xylitol-derived galacto-oligosaccharides and non-digestible lactulose derived carbohydrate mixtures
2024
Calvete-Torre, Inés | Sabater, Carlos | Delgado, Paloma | Muñoz Labrador, Ana | De Las Rivas, Blanca | Muñoz, Rosario | Corzo, Nieves | Moreno, F. Javier | Margolles Barros, Abelardo | Ruiz, Lorena | Agencia Estatal de Investigación (España) | Ministerio de Ciencia e Innovación (España) | European Commission | Sabater, Carlos[0000-0002-6098-895X] | Corzo, Nieves [0000-0002-6420-2344]
This study describes the microbiota modulatory properties of novel non-digestible galacto-oligosaccharides derived from xylitol and lactulose, through in vitro fecal batch fermentations. Differential analysis of microbiota profiles revealed the enhanced capacity to promote Bifidobacterium and Lactobacillus of the new galacto-oligosaccharides compared to commercial xylitol, among other genera. These novel galacto-oligosaccharides, especially those derived from the transgalactosylation of xylitol, led also to a high production of SCFAs, concretely in acetic acid, which were correlated with the promotion of several bacterial taxa. The reported fermentation patterns of these oligosaccharide structures could be of special interest to design novel prebiotic mixtures. Likewise, both xylitol and lactulose-derived galacto-oligosaccharides might exhibit slower fermentation rates compared to xylitol and lactulose controls due to the elongation of the carbohydrate chain, according to previous evidence. Therefore, novel prebiotic formulations based on xylitol and lactulose-derived galacto-oligosaccharides could promote the growth of beneficial gut commensals in the distal regions of the colon.
显示更多 [+] 显示较少 [-]AM and LR acknowledge PID2022-141737OB-I00 funded by MCIN/AEI/10.13039/501100011033 and FEDER, UE. FJM and NC acknowledge 2021AEP102 funded by MCIN/AEI within the State Plan for Scientific and Technical Research and Innovation (PEICTI).
显示更多 [+] 显示较少 [-]Peer reviewed
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