Antibody landscapes after influenza virus infection or vaccination.
2014
Fonville, JM | Wilks, SH | James, SL | Fox, A | Ventresca, M | Aban, M | Xue, L | Jones, TC | Le, NMH | Pham, QT | Tran, ND | Wong, Y | Mosterin, A | Katzelnick, LC | Labonte, D | Le, TT | van der Net, G | Skepner, E | Russell, CA | Kaplan, TD | Rimmelzwaan, GF | Masurel, N | de Jong, JC | Palache, A | Beyer, WEP | Le, QM | Nguyen, TH | Wertheim, HFL | Hurt, AC | Osterhaus, ADME | Barr, IG | Fouchier, RAM | Horby, PW | Smith, DJ
We introduce the antibody landscape, a method for the quantitative analysis of antibody-mediated immunity to antigenically variable pathogens, achieved by accounting for antigenic variation among pathogen strains. We generated antibody landscapes to study immune profiles covering 43 years of influenza A/H3N2 virus evolution for 69 individuals monitored for infection over 6 years and for 225 individuals pre- and postvaccination. Upon infection and vaccination, titers increased broadly, including previously encountered viruses far beyond the extent of cross-reactivity observed after a primary infection. We explored implications for vaccination and found that the use of an antigenically advanced virus had the dual benefit of inducing antibodies against both advanced and previous antigenic clusters. These results indicate that preemptive vaccine updates may improve influenza vaccine efficacy in previously exposed individuals.
显示更多 [+] 显示较少 [-]This is the author’s version of the work. It will be under embargo for 6 months following publication. It is posted here by permission of the AAAS for personal use, not for redistribution. The final version is available from AAAS in Science at http://www.sciencemag.org/content/346/6212/996.long.
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