THE INFLUENCE OF ANTITUMOR DRUG CIS-DDP ON PHYSICOCHEMICAL PROPERTIES OF DNA
2023
Sargsyan, Sh. A. | Antonyan, A. P. | Vardevanyan, P. O.
By the methods of UV spectroscopy and theoretical conformational analyses was investigated the structural peculiarities of DNA at complexformation with cis-DDP at extremal pH medium (pH< 4, pH>9). It was shown that by ionization of nitrogen bases, significant changes in Tm(pH) and ΔT(pH) take place. However, DNA-cis-DDP bidental interstand crosslink model and formation of chelates does not play а prior role at the platination.
显示更多 [+] 显示较少 [-]AGROVOC关键词
书目信息
出版者
Yerevan State University
其它主题
Structural peculiarities of dna; Complexformation; Ionization of nitrogen bases
语言
英语
格式
application/pdf
许可
Copyright (c) 2023 Proceedings of the YSU, https://creativecommons.org/licenses/by-nc/4.0/
ISSN
2953-7983, 1829-1767
类型
Info:eu-Repo/semantics/article; Info:eu-Repo/semantics/publishedversion
来源
Proceedings of the YSU B: Chemical and Biological Sciences; Vol. 42 No. 3 (217) (2008); 118-124, ԵՊՀ Գիտական տեղեկագիր. Քիմիական և կենսաբանական գիտություններ; Հտ․ 42 Հմր․ 3 (217) (2008); 118-124, ԵՊՀ Գիտական տեղեկագիր. Քիմիա և կենսաբանություն; Հտ․ 42 Հմր․ 3 (217) (2008); 118-124, Ученые записки ЕГУ: химические и биологические науки; Том 42 № 3 (217) (2008); 118-124, 2953-7983, 1829-1767, 10.46991/PYSUB.2008.42.3
2025-01-20
Dublin Core
