Oxidative Thermolysis of Sulfobutyl-Ether-Beta-Cyclodextrin Sodium Salt: A Kinetic Study
2025
Ionuț Ledeți | Claudia Temereancă | Amalia Ridichie | Adriana Ledeți | Denisa Laura Ivan | Gabriela Vlase | Titus Vlase | Carmen Tomoroga | Laura Sbârcea | Oana Suciu
Sulfobutyl-ether-beta-cyclodextrin sodium salt (SBECD) is a modified cyclodextrin widely used in the pharmaceutical industry to enhance the solubility and stability of poorly water-soluble drugs. As a derivative of beta-cyclodextrin, it is produced by introducing sulfobutyl ether groups into the beta-cyclodextrin molecule, which significantly increases its water solubility and decreases its toxicity compared to unmodified cyclodextrins. This study investigates the spectral and PXR diffraction characterization of SBECD, its thermal stability profile, and decomposition mechanism using isoconversional methods. Since the simple ASTM E698 method does not provide realistic data, the Flynn–Wall–Ozawa, Friedman, and NPK methods were employed, leading to the kinetic triplet that characterizes the oxidative thermolysis of this compound.
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