Fermented wheat "Hamoum" supplementation protects from bacterial translocation in malnourished rats.
2018
Bousbahi, Soumia | Benakriche, Ben Mehel | Gerard, Philippe | Kheroua, Omar | Université d'Oran 1 Ahmed Ben Bella [Oran] | Université Abdelhamid Ibn Badis de Mostaganem | MICrobiologie de l'ALImentation au Service de la Santé (MICALIS) ; Institut National de la Recherche Agronomique (INRA)-AgroParisTech | Université Paris Saclay (COmUE)
International audience
显示更多 [+] 显示较少 [-]英语. The present study was carried out to assess the effect of Fermented wheat Hamoum (FWH) on Bacterial Translocation in malnourished rats. Twenty-eight male Wistar rats weigthing 60 - 70 g and aged four weeks were used. Animals in Ct+ Group (malnourished group) were fed with protein malnutrition diet for 25 days; Group Ct- (negative control group) were fed with standard diet for 25 days. The remaining groups first received the protein malnutrition diet for 25 days before being fed for 25 days with different diets: diet supplemented with FWH (FWH Group) or standard diet (Std Group). Our results showed a high bacterial translocation rate in the Mesenteric Lymph Nodes (MLN), liver and spleen and morphological alterations in mucosal layers of the terminal ileum, in Ct+ group. In Ct - group there was no bacteria translocation in MLN, liver and spleen and there was a normal morphological appearance of the villus epithelium. In Std group, bacterial translocation was highly decreased in MLN and spleen, and not detected in liver. In FWH group, bacterial translocation was highly decreased in MLN and not detected in liver and spleen. Histological analysis showed that villous height and an intraepithelial lymphocytes (IELs) number were significantly decreased in the malnourished group. Conversely, in the FWH and Std group length of villi and IELs number were increased although the magnitude of the increase is lower in Std group than FWH Group.
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