Bacterial NHEJ: A never ending story
2019
Bertrand, Claire | Thibessard, Annabelle | Bruand, Claude | Lecointe, François | Leblond, Pierre | Dynamique des Génomes et Adaptation Microbienne (DynAMic) ; Institut National de la Recherche Agronomique (INRA)-Université de Lorraine (UL) | Laboratoire des interactions plantes micro-organismes (LIPM) ; Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS) | Université de Toulouse (UT) | MICrobiologie de l'ALImentation au Service de la Santé (MICALIS) ; Institut National de la Recherche Agronomique (INRA)-AgroParisTech | Université Paris-Saclay | INRA (Institut National de la Recherche Agronomique) ; Departement Sante des Plantes et Environnement ; French Laboratory of Excellence project TULIP : ANR-10-LABX-4 ; French National Research Agency program Streptoflux : ANR Blanc 0096_01 ; ANR through the Laboratory of Excellence ARBRE : ANR-12- LABXARBRE-01 | ANR-11-LABX-0002,ARBRE,Recherches Avancées sur l'Arbre et les Ecosytèmes Forestiers(2011)
International audience
显示更多 [+] 显示较少 [-]英语. Double-strand breaks (DSBs) are the most detrimental DNA damage encountered by bacterial cells. DBSs can be repaired by homologous recombination thanks to the availability of an intact DNA template or by Non-Homologous End Joining (NHEJ) when no intact template is available. Bacterial NHEJ is performed by sets of proteins of growing complexity from Bacillus subtilis and Mycobacterium tuberculosis to Streptomyces and Sinorhizobium meliloti. Here, we discuss the contribution of these models to the understanding of the bacterial NHEJ repair mechanism as well as the involvement of NHEJ partners in other DNA repair pathways. The importance of NHEJ and of its complexity is discussed in the perspective of regulation through the biological cycle of the bacteria and in response to environmental stimuli. Finally, we consider the role of NHEJ in genome evolution, notably in horizontal gene transfer.
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