Gut microbiome-modulating properties of a polyphenol-enriched dietary supplement comprised of hibiscus and lemon verbena extracts. Monitoring of phenolic metabolites
2022
Silva, Mariana | Cueva, Carolina | Alba, Claudio | Rodríguez, Juan M. | Pascual-Teresa, Sonia de | Jones, Jonathan | Caturla, Nuria | Moreno-Arribas, M. Victoria | Bartolomé, Begoña | Ministerio de Ciencia, Innovación y Universidades (España) | Agencia Estatal de Investigación (España) | Comunidad de Madrid
This paper investigates the impact of a polyphenol-enriched supplement comprised of hibiscus (Hibiscus sabdariffa) and lemon verbena (Lippia Citriodora) (brand name Metabolaid®) on gut microbiota composition and functionality, by performing fermentations with human faecal microbiota under gut-simulated conditions. Results indicated that Metabolaid®, in a dose-dependent manner, modulated the gut bacteriome to higher relative abundances of some major genera (>3% of relative abundance) such as Bifidobacterium, Blautia and Faecalibacterium and of other minor genera such as Prevotella and Akkermansia. Metabolaid® also promoted increases in short-chain fatty acids (SCFAs) production, particularly butyric acid. On the other hand, it was confirmed that the compounds present in the Metabolaid® supplement (anthocyanins, verbascoside and hibiscus acid) were rapidly metabolized by the gut microbiota. Overall, these results reveal a certain level of gut microbiota-modulating properties of Metabolaid® that could be implicated, at least partially, in the mechanisms behind the potential beneficial effects of this supplement in obesity.
显示更多 [+] 显示较少 [-]Part of this work was funded by Monteloeder S. L. (Alicante, Spain). Additional funding came from grants PID2019-108851RB-C21 (Spanish Ministry of Science and Innovation, Spain), and ALIBIRD-CM 2020 P2018/BAA-4343 (Community of Madrid, Spain).
显示更多 [+] 显示较少 [-]Peer reviewed
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