Detection of high incidence of K-ras oncogenes during human colon tumorigenesis
1987
Forrester, K. | Almoguera, Concepción | Han, K | Asahi Kasei Corporation | National Cancer Institute (US)
RNAse A mismatch cleavage analysis of 66 primary human colon tumours reveals a high incidence of K-ras genes with mutations at position 12. No apparent correlation was found between the presence of mutant oncogenes and the degree of invasiveness of the tumours but evidence for ras mutational activation in premalignant tissue was obtained.
显示更多 [+] 显示较少 [-]This work was supported by an NIH grant awarded by tbe Nalional Cancer Institute and by a grant from Toyo Jozo Ltd.
显示更多 [+] 显示较少 [-]Peer reviewed
显示更多 [+] 显示较少 [-]