Safety and efficacy of L-arginine produced by fermentation with Escherichia coli NITE BP-02186 for all animal species
2018
(FEEDAP), EFSA Panel on Additives and Products or Substances used in Animal Feed
L-Arginine is considered as a non-essential amino acid for most adult mammalian species, but it is classified as essential for birds, fish, possibly reptiles and also for strict carnivores. L-Arginine produced by fermentation with Escherichia coli NITE BP-02186, genetically modified to enhance the production of L-arginine, is intended to be used in feed and water for drinking for all animal species and categories. The product under assessment does not give rise to any safety concern with regard to the genetic modification of the production strain. Its use as a nutritional additive is safe for target species when supplemented to diets in appropriate amounts. The use of L-arginine as a feed flavouring agent is unlikely to pose any concern. No risks are expected for the consumer from the use of the product under assessment as a feed additive. It is not irritant to skin or eyes, nor a skin sensitiser. Although the presence of endotoxin activity is of no concern, the available exposure and toxicological data indicate that the additive may pose a risk to users by inhalation. The use of this additive in animal nutrition does not pose a risk to the environment. The additive is an effective source of arginine for all species. L-Arginine is considered efficacious when used as a flavouring compound in animal nutrition.
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书目信息
出版者 Wiley
ISSN 1831-4732