Generalized fatal Cowpox virus infection in a cat with transmission to a human contact case
2007
Schulze, C. | Alex, M. | Schirrmeier, Horst | Hlinak, A. | Engelhardt, A. | Koschinski, B. | Beyreiss, B. | Hoffmann,M. | Czerny, C.P.
A 4-month-old female domestic shorthair cat was infected by a virus of the Poxvirus family. The animal developed a severe pneumonia and generalized ulcerating lesions of the skin. Histologically, typical eosinophilic intracytoplasmic inclusion bodies indicative of an Orthopoxvirus (OPV) infection were present. The lung showed grey-white to haemorrhagic nodular lesions with a central zone of complete necrosis of alveolar and bronchial tissue. Electron microscopy from skin and lung nodules revealed typical square-shaped OPV particles. Cultivation of the virus on chorio-allantoic membranes of embryonated chicken eggs resulted in haemorrhagic plaques. Restriction enzyme analysis, PCR and sequencing of the D8L gene identified the OPV isolate as a typical Cowpox virus. It was transmitted by the cat to a human contact person who developed a local nodular dermatitis at the inoculation site in association with signs of general infection and had an increase of OPV-specific neutralizing antibodies in paired serum samples
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书目信息
出版者 Wiley-Blackwell
ISSN 1863-1959 | 1863-2378 | 1863-2378