Novel conjugative plasmid from Escherichia coli of swine
origin that co-harbors the multi-resistance gene cfr and the
3 extended-spectrum β-lactamase gene blaCTX-M-14b

Zhang, W.J.; Wang, X.M.; Dai, L.; Hua,X.; Dong, Z.; Schwarz, Stefan; Liu, S.

Novel conjugative plasmid from Escherichia coli of swine origin that co-harbors the multi-resistance gene cfr and the 3 extended-spectrum β-lactamase gene blaCTX-M-14b

2014

Two porcine Escherichia coli isolates harbored the cfr gene on conjugative plasmids of 38,405 bp (pGXEC6) and 41,646 bp (pGXEC3). In both plasmids, the cfr gene was located within a 4,612-bp region containing a tnpA-IS26-cfr-IS26-Δhyp element. Plasmid pGXEC3 was almost identical to pGXEC6, except for a 3,235-bp ISEcp1-blaCTX-M-14b insertion. The co-location of the multi-resistance gene cfr with an extended-spectrum β-lactamase gene on a conjugative plasmid may support the dissemination of both genes by co-selection.

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