Adipose-derived stem cells decreased microglia activation and protected dopaminergic loss in rat lipopolysaccharide model
2019
Muñoz Pinto, Mario Faustino | Argüelles Castilla, Sandro | Medina, Rafael | Cano Rodríguez, María Mercedes | Ayala Gómez, Antonio | Universidad de Sevilla. Departamento de Fisiología | Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular | Junta de Andalucía
Adult stem cell therapy is being used extensively to rejuvenate damaged tissue. One important tissue source to obtain these cells is adipose, which contains cells called adipose-derived stem cells (ADSCs). These cells have a great therapeutic potential not only for their multipotent properties as well as for immunomodulatory effects on the immune system. Parkinson's disease is characterized as neurodegenerative disorder which etiology is undoubtedly related to neuroinflammation process. The properties of ADSCs can be used as a new tool in stem cells therapy to treat neurodegenerative disorders. However, their efficacies are still controversial. Some authors have reported neuroprotection effects, while others did not find differences or stem cells increased the damage. Our previous study showed that ADSCs can survive long time after transplantation, suggesting us some biological effects could need more time to be repaired. In this study, we assessed the neuroprotection 6 months after transplantation. Our results suggest ADSCs can protect the dopaminergic loss after lipopolysaccharide (LPS) injection both reducing the microglia activation and differentiating into dopaminergic cells.
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