Palladium-catalyzed amino group arylation of 1,3-disubstituted 1H-pyrazol-5-amine based on Buchwald–Hartwig reaction
Mateusz Kucharek | Andrzej Danel
英语. An efficient Pd-catalyzed C–N bond formation for the synthesis of different pyrazole derivatives using XPhos as a ligand and KOH as a base is presented. The developed procedure can be successfully applied for the synthesis of 5-N-aryl-1,3-disubstituted 1H-pyrazol5-amines. Contrary to previously described procedures, this one proceeds in one step utilizing commercially available aminopyrazoles and aryl halides. Thus, a series of 5-N-aryl-1,3-disubstituted 1H-pyrazol-5-amines were obtained with satisfactory yields under optimized reaction conditions.
显示更多 [+] 显示较少 [-]英语. 5-N-arylaminopyrazoles, palladium catalyst, arylation, cross coupling
显示更多 [+] 显示较少 [-]633-639
显示更多 [+] 显示较少 [-]57 (6)
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