Cardiovascular Effects of Dexmedetomidine-Ketamine Compared with Thiopental Sodium in Sevoflurane Anesthetized Goats
2022
Karslı, Birkan | Kumandaş, Ali | Pekcan, Zeynep
The objective of the study is to compare the efficacy and cardiopulmonary effects of dexmedetomidine-ketamine and thiopental sodium in sevoflurane anesthetized in goats. Seven healthy adult female goats with body weight of 35.3±3.82 kg (median±IQ). Each goat received both anesthetics in a randomized cross-over design, with at least 2 weeks intervals. Anesthesia was induced with intravenous dexmedetomidine (2 mg/kg) and ketamine (10 mg/kg) or thiopental sodium (19.3±3.42 mg/kg) (mean±SD) and maintained with sevoflurane for 2 hours. Arterial blood pressure, heart rate (HR), respiratory rate (RR) and arterial blood gases were monitored. Induction of anesthesia was smooth in all goats. Mean recovery times were significantly longer in thiopental sodium group (P<0.05). Side effects were less common in dexmedetomidine-ketamine group (DKS) than thiopental sodium group (TS). Recovery was uneventful in both groups. Although the mean arterial blood pressures (MAP) were decreased in both groups (P<0.05), the prolonged decrease was recorded in DKS group. The temperature was decreased in both groups in time (P<0.05). Changes in blood oxygenation were significantly higher in DKS group at 15 and 120 minutes compared to TS group (P<0.05). Dexmedetomidine-ketamine provides better anesthesia when compare with thiopental sodium as an induction agent before sevoflorane anesthesia in goats.
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