Intestinal Integrity Assessment with Diamine Oxidase Activity in Dogs with Atopic Dermatitis
2023
Ural, Kerem
Diamin oxidase (dAo) as a valuable biomarker, and a mirror of the integrity/mucosal function of the small intestine (sint). The levels of dAo in the serum and mucosa of the sint could be capable of determining as an assessment of sint barrier function. Given better understanding of gut-brain-skin axis in veterinary internal medicine field, relevant data is lacking through dogs with atopic dermatitis (atode) in which resarches focus and rely on skin changes. However more data is crucial, which prompted the present author to perform this study and analyzed the relationship between integrity/mucosal function of sint to those of dogs with atode. Dogs enrolled and classified as suggested criterion for mild (10), moderate (35) and severe (60) skin lesions scoring based on CADESI-04. Commercially available Canine Diamine Oxidase ELISA Kit were purchased for dAo analytes. As detected by Quantitave Competitive ELISA, dAo levels (ng/mL) were detected as 5,28±1,19, 2,594±0,76 and 1,28±0,22, with a statistical significance of Group III in contrast to Group I, suggesting that as severity of the atode elevates, circulating dAo levels were declined in correlation. It should not be unwise to draw preliminary suggestion that dAo levels could alter in relationship with disease activity in dogs with atode. This alterations, mainly deduction, should reflect diasease activity, in which dogs in Group III (severe atode) represented lowest dAo values in contrasto to other classfied groups of disease.
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