Unraveling Microbiome: The Role of Microbiota in Patients’ Response to Oncological Treatment and Its Influence on Host-biochemistry
2021
Akanbong, Elisha Apatewen | Şenol, Ali | Sudağıdan, Mert | Devrim, Alparslan Kadir
Despite the implication of viruses and bacteria in oncogenesis, commensal microbes play a beneficial role in anticancer therapy. Microbiota regulates responses made to various types of cancer chemotherapy by affecting the mechanism of action and toxicity of these therapies. From birth, microbiota confers innate and acquired immune responses and its role in modulating health and diseases has recently been appreciated. Increasing evidence also suggests that microbiota affects the pattern of body energy balance thus; they have a correlation with obesity, obesity-related complications and insulin resistance. Hence, microbiota has attracted the interest of researchers. However, there is little, if any, robust evidence-based review on their role in patients’ response to cancer therapy and their influence on host-biochemistry thus, this review aimed to achieve that.
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