Preparation and Evaluation of Anti-Emetic Ginger Orodispersible Tablets from Standardized Extract using Phenolic Profile Effects
2024
Asawahame, C. | Klangklang, S. | Auklarapa, P. | Indranupakorn, R.
Ginger (Zingiber officinale Roscoe) is widely utilized in Thailand’s healthcare system to alleviate motion sickness-induced nausea and vomiting. Its anti-emetic properties are attributed to various phenolic constituents, primarily gingerols and shogaols, which can vary due to processing and environmental factors. Tracking these compounds is quite complex. Therefore, this study aims to scientifically verify a practical quantitative approach for assessing active constituents, in terms of phenolic profiles, using ginger orodispersible tablets (ODTs) from standardized extracts as the target. The standardized ginger extract, quantified in 6-gingerol via validated HPLC, was combined with the superdisintegrant, sodium starch glycolate, using the wet granulation technique to prepare the ODTs. The optimized formulation met Pharmacopoeia standards, exhibiting desirable characteristics that can be used as a sample prototype for assessing the total phenolic content (TPC) using the modified Folin-Ciocalteu (F-C) assay. Determining the phenolic profiles in both the standardized ginger extracts and the tablets proved effective, facilitating the accurate quantification of total active constituents. This was particularly useful for handling multiple samples during dissolution tests. This study contributes to frontier knowledge on the phenolic profiles in standardized ginger extracts and theirs ODTs, which play an important role in interpreting the amounts of active constituents in the ODTs for their antiemetic properties.
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