Associations of leptin gene polymorphisms with production traits in pigs.
2006
PEIXOTO, J. DE O. | GUIMARÃES, S. E. F. | LOPES, P. S. | SOARES, M. A. M. | PIRES, A. V. | BARBOSA, M. V. G. | TORRES, R. DE A. | SILVA, M. DE A. E. | J. de Oliveira Peixoto, UFV; S. E. Facioni Guimarães, UFV; P. Sávio Lopes, UFV; M. A. Menck Soares, UNIOESTE; A. Vieira Pires UFVJM Diamantina MG; Marcos Vinicius Gualberto Barbosa da Silva, Embrapa Gado de Leite; Robledo de Almeida Torres, UFV; M. de Almeida Silva, UFMG.
The associations of leptin (LEP) gene polymorphisms C798T, T2411C, T3266G and T3469C with production traits were investigated in a F2 pig population produced by divergent crosses. The statistical model included genotype, sex, batch and genotype by sex interaction as fixed effects and sire as random effect. Polymorphism C798T was associated with variation in total teat number (p < 0.02) and left teat number (p < 0.03), and polymorphism T3469C was associated with weight at 21 days (p < 0.03), 42 days (p < 0.05), 63 days (p < 0.02) and 77 days of age (p < 0.04) as well as feed intake (p < 0.01), average daily gain (p < 0.01), feed conversion (p < 0.01), bacon depth (p < 0.03) and slaughter weight (p < 0.03). Phenotypic associations were also performed by combining T3469C and C798T genotypes. Interaction between C798T genotypes and sex was observed for some traits. LEP genotypes had significant influence on performance traits, and can be considered as potential genetic markers for selection. However, these results have to be validated in commercial herds.
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