The tissue distribution of nucleobindin-2/nesfatin-1 in the reproductive organs of bitches with regard to the animal’s age and body weight

Rybska Marta; Skrzypski Marek; Pusiak Karolina; Wojciechowicz Tatiana; Mieldzioc Adam

The tissue distribution of nucleobindin-2/nesfatin-1 in the reproductive organs of bitches with regard to the animal’s age and body weight

2025

Rybska Marta | Skrzypski Marek | Pusiak Karolina | Wojciechowicz Tatiana | Mieldzioc Adam

Neuropeptide nesfatin-1, a nucleobindin-2 derivative, plays a role in regulating food intake, energy metabolism and body weight. It also interacts with the hypothalamic-pituitary-gonadal axis and has functions in the reproductive system. However, its impact on the canine reproductive tract has not been well documented. This study aimed to investigate the potential role of nesfatin-1 in canine ovarian activity and uterine function.

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