Developmental Origins of Health and Disease in swine: implications for animal production and biomedical research
2016
Gonzalez-Bulnes, A. | Astiz, S. | Ovilo, C. | Lopez-Bote, C.J. | Torres-Rovira, Laura | Barbero, A. | Ayuso, M. | Garcia-Contreras, C. | Vazquez-Gomez, M. | Comparative Physiology Laboratory | Department of Veterinary Medicine ; Università degli Studi di Sassari = University of Sassari [Sassari] (UNISS) | Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria = National Institute for Agricultural and Food Research and Technology (INIA) | Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM) | Biologie du Développement et Reproduction (BDR) ; École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA)
Thanks for the help excellent of Pascale Chavatte-Palmer
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显示更多 [+] 显示较少 [-]英语. The concept of Developmental Origins of Health and Disease (DOHaD) addresses, from a large set of epidemiological evidences in human beings and translational studies in animal models, both the importance of genetic predisposition and the determinant role of maternal nutrition during pregnancy on adult morphomics and homeostasis. Compelling evidences suggest that both overnutrition and undernutrition may modify the intrauterine environment of the conceptus and may alter the expression of its genome and therefore its phenotype during prenatal and postnatal life. In fact, the DOHaD concept is an extreme shift in the vision of the factors conditioning adult phenotype and supposes a drastic change from a gene-centric perspective, only modified by lifestyle and nutritional strategies during juvenile development and adulthood, to a more holistic approach in which environmental, parental, and prenatal conditions are strongly determining postnatal development and homeostasis. The implications of DOHaD are profound in all the mammalian species and the present review summarizes current knowledge on causes and consequences of DOHaD in pigs, both for meat production and as a well-recognized model for biomedicine research.
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