Odoribacter splanchnicus—A Next-Generation Probiotic Candidate
2025
Jianhong Li | Jing Xu | Xue Guo | Haoming Xu | Chen Huang | Yuqiang Nie | Youlian Zhou
As an important intestinal microorganism, <i>Odoribacter splanchnicus</i> frequently appears in high-throughput sequencing analyses, although pure culture research on this microorganism is not as advanced. It is widely present in the mammalian gut and is closely associated with the health status of the host and the incidence of various diseases. In recent years, changes in the abundance of <i>O. splanchnicus</i> have been found to be positively or negatively correlated with health issues, such as obesity, metabolic syndrome, diabetes, and intestinal inflammation. It may exhibit a dual protective or promotional role in specific diseases. Thus, it may play an important role in regulating host metabolism, immune response, and intestinal homeostasis. Additional research has revealed that <i>O. splanchnicus</i> can synthesize various metabolites, especially short-chain fatty acids (SCFAs), which play a key role in promoting intestinal health, enhancing energy metabolism, improving insulin resistance, and regulating immune responses in the host. Therefore, <i>O. splanchnicus</i> is a strong candidate for “next-generation probiotics”, and its potential probiotic function provides novel ideas for the development of functional foods and the prevention and treatment of metabolic and intestinal inflammatory diseases. These findings can help develop new biological treatment strategies and optimize health management plans.
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