THE IN VITRO SENSITIVITY PATTERNS PF BACTERIA ISOLATED FROM URINARY TRACT INFECTIONS TO 11 COMMONLY PRESCRIBED ANTIMICROBIAL DRUGS.
2009
Lamyaa Kadhum Bakir
Due to an increase in the number of resistant bacterial strains that cause urinary tract infection (UTI), empirical treatment with the commonly prescribed antimicrobials might be inadequate. This prospective study was conducted on 252 adult patients with uncomplicated urinary tract infection aiming at optimizing the use of empirical antibacterial therapy through identification of the causative bacteria and studying their in vitro sensitivity patterns to 11 commonly prescribed antimicrobial drugs. This study showed that gram negative bacteria were the most frequent cause of UTI accounting for 95.3% of cases, with strains of Escherichia coli alone responsible for 50% of all infections. The study also recorded an increase in the rate of infection caused by Klebsilla which was reported in 28.6% of cases. Combined drug therapy was not superior to single antimicrobial. Agumentin or Co- trimoxazole were effective against only 78.6% and 43.7% of the tested bacterial strains. Single drug treatment using the aminoglycoside, Amikacin (92.9% bacterial sensitivity rate) or the third generation cephalosporin, Cefotaxime (88.9% bacterial sensitivity rate) might be the first choice for injectable drug treatment and ciprofloxacin (81% bacterial sensitivity) for orai therapy. It is concluded that periodic reevaluation of bacterial etiology and antimicrobial resistance studies and needed for better empirical treatment of uncomplicated UTI through the avoidance of continuous bacterial resistance to such treatment.
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